Drug interactions
Dapagliflozin-metformin + Lithium
Severity: Moderate
Dapagliflozin-metformin and Lithium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
SGLT2 inhibitors such as dapagliflozin may lower serum lithium concentrations, potentially reducing mood-stabilizing effect. Because lithium has a narrow therapeutic range, changes in levels after starting or stopping the combination matter clinically.
What this interaction means in plain words
Dapagliflozin-metformin and Lithium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dapagliflozin-metformin belongs to Endocrine; Lithium belongs to Central Nervous System.
Why it happens
The mechanism is not firmly established; altered renal sodium and lithium handling from SGLT2 inhibition is suspected.
What to do
Measure serum lithium more often when starting, stopping or changing the dapagliflozin dose, and adjust the lithium dose according to levels and clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dapagliflozin-metformin
Other interactions of Lithium
- Lithium + Thioridazine Contraindicated
- Lithium + Vandetanib Contraindicated
- Aceclofenac + Lithium Major
- Acemetacin + Lithium Major
- Amisulpride + Lithium Major
- Amlodipine-benazepril + Lithium Major
Frequently asked questions
Can I take Dapagliflozin-metformin with Lithium?
MediHelp rates the interaction as moderate. Dapagliflozin-metformin and Lithium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. SGLT2 inhibitors such as dapagliflozin may lower serum lithium concentrations, potentially reducing mood-stabilizing effect. Because lithium has a narrow therapeutic range, changes in levels after starting or stopping the combination matter clinically.
How serious is the interaction between Dapagliflozin-metformin and Lithium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Measure serum lithium more often when starting, stopping or changing the dapagliflozin dose, and adjust the lithium dose according to levels and clinical response.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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