Drug interactions
Dapagliflozin-metformin + Lofepramine
Severity: Minor
Dapagliflozin-metformin and Lofepramine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants such as lofepramine may alter glycemic control and in some patients enhance the effect of antidiabetic drugs. With metformin and dapagliflozin the hypoglycemia risk is low and the effect is usually minor.
What this interaction means in plain words
Dapagliflozin-metformin and Lofepramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive glucose lowering through altered insulin sensitivity; the mechanism is not well established.
What to do
Check blood glucose when lofepramine is started or stopped; no routine dose change is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dapagliflozin-metformin
Frequently asked questions
Can I take Dapagliflozin-metformin with Lofepramine?
MediHelp rates the interaction as minor. Dapagliflozin-metformin and Lofepramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tricyclic antidepressants such as lofepramine may alter glycemic control and in some patients enhance the effect of antidiabetic drugs. With metformin and dapagliflozin the hypoglycemia risk is low and the effect is usually minor.
How serious is the interaction between Dapagliflozin-metformin and Lofepramine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check blood glucose when lofepramine is started or stopped; no routine dose change is needed.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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