Drug interactions
Dapagliflozin-metformin + Lonapegsomatropin
Severity: Moderate
Dapagliflozin-metformin and Lonapegsomatropin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Growth hormone can reduce insulin sensitivity and raise blood glucose, particularly at higher doses. Patients with diabetes may need more antihyperglycemic therapy after starting it.
What this interaction means in plain words
Dapagliflozin-metformin and Lonapegsomatropin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dapagliflozin-metformin belongs to Endocrine; Lonapegsomatropin belongs to Endocrine.
Why it happens
Growth hormone induces insulin resistance and increases hepatic glucose output and lipolysis.
What to do
Monitor blood glucose closely when starting or adjusting lonapegsomatropin and adjust antidiabetic doses as required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dapagliflozin-metformin
Other interactions of Lonapegsomatropin
Frequently asked questions
Can I take Dapagliflozin-metformin with Lonapegsomatropin?
MediHelp rates the interaction as moderate. Dapagliflozin-metformin and Lonapegsomatropin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Growth hormone can reduce insulin sensitivity and raise blood glucose, particularly at higher doses. Patients with diabetes may need more antihyperglycemic therapy after starting it.
How serious is the interaction between Dapagliflozin-metformin and Lonapegsomatropin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely when starting or adjusting lonapegsomatropin and adjust antidiabetic doses as required.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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