Drug interactions
Dapagliflozin-metformin + Methylene blue
Severity: Moderate
Dapagliflozin-metformin and Methylene blue: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methylene blue has been shown to inhibit renal cation transporters, which can reduce metformin elimination and raise its exposure. This may increase the risk of metformin accumulation and lactic acidosis, particularly with impaired renal function.
What this interaction means in plain words
Dapagliflozin-metformin and Methylene blue can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Methylene blue is thought to inhibit MATE and OCT2 transporters, decreasing renal tubular secretion of metformin.
What to do
Monitor glycemic control, renal function and signs of lactic acidosis during methylene blue use. Consider temporarily holding metformin or lowering its dose if prolonged exposure is expected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dapagliflozin-metformin
Frequently asked questions
Can I take Dapagliflozin-metformin with Methylene blue?
MediHelp rates the interaction as moderate. Dapagliflozin-metformin and Methylene blue can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methylene blue has been shown to inhibit renal cation transporters, which can reduce metformin elimination and raise its exposure. This may increase the risk of metformin accumulation and lactic acidosis, particularly with impaired renal function.
How serious is the interaction between Dapagliflozin-metformin and Methylene blue?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glycemic control, renal function and signs of lactic acidosis during methylene blue use. Consider temporarily holding metformin or lowering its dose if prolonged exposure is expected.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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