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Drug interactions

Dapagliflozin-metformin + Methyltestosterone

Severity: Minor

Dapagliflozin-metformin and Methyltestosterone: minor interaction.

Last updated

For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.

Summary

Androgens such as methyltestosterone may improve insulin sensitivity and lower blood glucose, which can add to the effect of antidiabetic drugs. Clinically meaningful hypoglycemia is unlikely with metformin and dapagliflozin.

What this interaction means in plain words

Dapagliflozin-metformin and Methyltestosterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.

Evidence level: Low

Why it happens

Androgens may enhance insulin sensitivity, producing an additive glucose-lowering effect.

What to do

Monitor blood glucose when methyltestosterone is started or stopped and adjust antidiabetic doses only if needed.

What to ask your pharmacist

  • Is there anything I should notice while taking both?
  • Do I need to tell my doctor at the next visit?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Frequently asked questions

Can I take Dapagliflozin-metformin with Methyltestosterone?

MediHelp rates the interaction as minor. Dapagliflozin-metformin and Methyltestosterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Androgens such as methyltestosterone may improve insulin sensitivity and lower blood glucose, which can add to the effect of antidiabetic drugs. Clinically meaningful hypoglycemia is unlikely with metformin and dapagliflozin.

How serious is the interaction between Dapagliflozin-metformin and Methyltestosterone?

MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when methyltestosterone is started or stopped and adjust antidiabetic doses only if needed.

What other medicines interact with Dapagliflozin-metformin?

MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.

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