Drug interactions
Dapagliflozin-metformin + Olanzapine
Severity: Moderate
Dapagliflozin-metformin and Olanzapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olanzapine commonly causes weight gain, insulin resistance and hyperglycemia, which can counteract antidiabetic therapy. Loss of glycemic control and diabetic ketoacidosis have been reported with this drug.
What this interaction means in plain words
Dapagliflozin-metformin and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dapagliflozin-metformin belongs to Endocrine; Olanzapine belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism through antipsychotic-induced insulin resistance and impaired glucose regulation.
What to do
Monitor fasting glucose and HbA1c at baseline and regularly during olanzapine therapy, and intensify antidiabetic treatment as needed. Consider a less metabolically active antipsychotic if control deteriorates.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dapagliflozin-metformin
Other interactions of Olanzapine
Frequently asked questions
Can I take Dapagliflozin-metformin with Olanzapine?
MediHelp rates the interaction as moderate. Dapagliflozin-metformin and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olanzapine commonly causes weight gain, insulin resistance and hyperglycemia, which can counteract antidiabetic therapy. Loss of glycemic control and diabetic ketoacidosis have been reported with this drug.
How serious is the interaction between Dapagliflozin-metformin and Olanzapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor fasting glucose and HbA1c at baseline and regularly during olanzapine therapy, and intensify antidiabetic treatment as needed. Consider a less metabolically active antipsychotic if control deteriorates.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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