Drug interactions
Dapagliflozin-metformin + Ombitasvir / paritaprevir / ritonavir and dasabuvir
Severity: Moderate
Dapagliflozin-metformin and Ombitasvir / paritaprevir / ritonavir and dasabuvir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
This regimen is not expected to markedly alter metformin exposure, but ritonavir-containing regimens and hepatitis C treatment can change glycemic control. Metformin carries a lactic acidosis risk in renal or hepatic impairment, which are common in this population.
What this interaction means in plain words
Dapagliflozin-metformin and Ombitasvir / paritaprevir / ritonavir and dasabuvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible transporter effects on metformin plus changing glycemic control as hepatitis C is treated; mechanism not fully established.
What to do
Monitor renal function, glucose and signs of lactic acidosis. Avoid metformin in significant renal or hepatic impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dapagliflozin-metformin
Frequently asked questions
Can I take Dapagliflozin-metformin with Ombitasvir / paritaprevir / ritonavir and dasabuvir?
MediHelp rates the interaction as moderate. Dapagliflozin-metformin and Ombitasvir / paritaprevir / ritonavir and dasabuvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. This regimen is not expected to markedly alter metformin exposure, but ritonavir-containing regimens and hepatitis C treatment can change glycemic control. Metformin carries a lactic acidosis risk in renal or hepatic impairment, which are common in this population.
How serious is the interaction between Dapagliflozin-metformin and Ombitasvir / paritaprevir / ritonavir and dasabuvir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function, glucose and signs of lactic acidosis. Avoid metformin in significant renal or hepatic impairment.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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