Drug interactions
Dapagliflozin-metformin + Phenytoin
Severity: Moderate
Dapagliflozin-metformin and Phenytoin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenytoin can inhibit insulin release and cause hyperglycemia, which may reduce antidiabetic effect. Glucose may fall again when phenytoin is stopped.
What this interaction means in plain words
Dapagliflozin-metformin and Phenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dapagliflozin-metformin belongs to Endocrine; Phenytoin belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism through phenytoin inhibition of pancreatic insulin secretion.
What to do
Monitor blood glucose when starting, stopping or changing the phenytoin dose, and adjust antidiabetic therapy accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dapagliflozin-metformin
Other interactions of Phenytoin
- Artemether / lumefantrine + Phenytoin Contraindicated
- Bictegravir + Phenytoin Contraindicated
- Cabotegravir + Phenytoin Contraindicated
- Doravirine + Phenytoin Contraindicated
- Elbasvir / grazoprevir + Phenytoin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Phenytoin Contraindicated
Frequently asked questions
Can I take Dapagliflozin-metformin with Phenytoin?
MediHelp rates the interaction as moderate. Dapagliflozin-metformin and Phenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenytoin can inhibit insulin release and cause hyperglycemia, which may reduce antidiabetic effect. Glucose may fall again when phenytoin is stopped.
How serious is the interaction between Dapagliflozin-metformin and Phenytoin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting, stopping or changing the phenytoin dose, and adjust antidiabetic therapy accordingly.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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