Drug interactions
Dapagliflozin-metformin + Procainamide
Severity: Moderate
Dapagliflozin-metformin and Procainamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Procainamide and its active metabolite are cationic drugs eliminated partly by renal tubular secretion, and metformin uses the same pathway. Concurrent use may raise exposure to either drug, increasing the risk of procainamide toxicity such as arrhythmia or QRS/QT prolongation, and of metformin accumulation.
What this interaction means in plain words
Dapagliflozin-metformin and Procainamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Competition for renal tubular cationic transporters (OCT2/MATE) reduces the clearance of both drugs.
What to do
Monitor ECG and procainamide plasma concentrations and watch for signs of metformin excess, including GI upset and lactic acidosis. Reduce the dose of either drug if toxicity appears, especially in renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dapagliflozin-metformin and Procainamide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Dapagliflozin-metformin
Frequently asked questions
Can I take Dapagliflozin-metformin with Procainamide?
MediHelp rates the interaction as moderate. Dapagliflozin-metformin and Procainamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Procainamide and its active metabolite are cationic drugs eliminated partly by renal tubular secretion, and metformin uses the same pathway. Concurrent use may raise exposure to either drug, increasing the risk of procainamide toxicity such as arrhythmia or QRS/QT prolongation, and of metformin accumulation.
How serious is the interaction between Dapagliflozin-metformin and Procainamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and procainamide plasma concentrations and watch for signs of metformin excess, including GI upset and lactic acidosis. Reduce the dose of either drug if toxicity appears, especially in renal impairment.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
