Drug interactions
Dapagliflozin-metformin + Progesterone micronized
Severity: Minor
Dapagliflozin-metformin and Progesterone micronized: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral micronized progesterone may modestly reduce insulin sensitivity and raise blood glucose, partly opposing the effect of metformin. The effect is generally small but could matter in patients with marginal glycemic control.
What this interaction means in plain words
Dapagliflozin-metformin and Progesterone micronized have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Pharmacodynamic antagonism through progestogen-related decreases in insulin sensitivity.
What to do
Check blood glucose more often after starting or stopping progesterone and adjust the antidiabetic regimen if control changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dapagliflozin-metformin
Frequently asked questions
Can I take Dapagliflozin-metformin with Progesterone micronized?
MediHelp rates the interaction as minor. Dapagliflozin-metformin and Progesterone micronized have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oral micronized progesterone may modestly reduce insulin sensitivity and raise blood glucose, partly opposing the effect of metformin. The effect is generally small but could matter in patients with marginal glycemic control.
How serious is the interaction between Dapagliflozin-metformin and Progesterone micronized?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check blood glucose more often after starting or stopping progesterone and adjust the antidiabetic regimen if control changes.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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