Drug interactions
Dapagliflozin-metformin + Progesterone natural
Severity: Minor
Dapagliflozin-metformin and Progesterone natural: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Natural progesterone may slightly reduce insulin sensitivity and raise glucose, opposing metformin's glucose-lowering action. The effect is typically small and manageable.
What this interaction means in plain words
Dapagliflozin-metformin and Progesterone natural have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Pharmacodynamic antagonism through progestogen-related insulin resistance.
What to do
Monitor blood glucose when progesterone is started, changed or stopped, and adjust antidiabetic dosing if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dapagliflozin-metformin
Frequently asked questions
Can I take Dapagliflozin-metformin with Progesterone natural?
MediHelp rates the interaction as minor. Dapagliflozin-metformin and Progesterone natural have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Natural progesterone may slightly reduce insulin sensitivity and raise glucose, opposing metformin's glucose-lowering action. The effect is typically small and manageable.
How serious is the interaction between Dapagliflozin-metformin and Progesterone natural?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when progesterone is started, changed or stopped, and adjust antidiabetic dosing if needed.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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