Drug interactions
Dapagliflozin-metformin + Quinapril
Severity: Moderate
Dapagliflozin-metformin and Quinapril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors may enhance insulin sensitivity and occasionally cause hypoglycemia in patients on antidiabetic drugs. Also, ACE inhibitors can reduce renal function in susceptible patients, which may lead to metformin accumulation and lactic acidosis, and can worsen volume depletion with dapagliflozin.
What this interaction means in plain words
Dapagliflozin-metformin and Quinapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
ACE inhibition may improve insulin sensitivity and can reduce renal perfusion, decreasing metformin clearance; the evidence is mixed.
What to do
Monitor blood glucose and renal function (eGFR) after starting or adjusting quinapril. Hold metformin if renal function deteriorates significantly or volume depletion occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dapagliflozin-metformin
Frequently asked questions
Can I take Dapagliflozin-metformin with Quinapril?
MediHelp rates the interaction as moderate. Dapagliflozin-metformin and Quinapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors may enhance insulin sensitivity and occasionally cause hypoglycemia in patients on antidiabetic drugs. Also, ACE inhibitors can reduce renal function in susceptible patients, which may lead to metformin accumulation and lactic acidosis, and can worsen volume depletion with dapagliflozin.
How serious is the interaction between Dapagliflozin-metformin and Quinapril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and renal function (eGFR) after starting or adjusting quinapril. Hold metformin if renal function deteriorates significantly or volume depletion occurs.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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