Drug interactions
Dapagliflozin-metformin + Sulfamethoxypyridazine
Severity: Minor
Dapagliflozin-metformin and Sulfamethoxypyridazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfonamide antibacterials can occasionally enhance the hypoglycemic effect of antidiabetic drugs. Metformin alone rarely causes hypoglycemia, so the risk is low, but it increases when combined with other glucose-lowering agents or in renal impairment.
What this interaction means in plain words
Dapagliflozin-metformin and Sulfamethoxypyridazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Sulfonamides may have an intrinsic insulin-secretagogue effect; the mechanism is not well established.
What to do
Monitor blood glucose during the antibacterial course, especially if other glucose-lowering drugs are used or renal function is reduced.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dapagliflozin-metformin
Frequently asked questions
Can I take Dapagliflozin-metformin with Sulfamethoxypyridazine?
MediHelp rates the interaction as minor. Dapagliflozin-metformin and Sulfamethoxypyridazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sulfonamide antibacterials can occasionally enhance the hypoglycemic effect of antidiabetic drugs. Metformin alone rarely causes hypoglycemia, so the risk is low, but it increases when combined with other glucose-lowering agents or in renal impairment.
How serious is the interaction between Dapagliflozin-metformin and Sulfamethoxypyridazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during the antibacterial course, especially if other glucose-lowering drugs are used or renal function is reduced.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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