Drug interactions
Dapagliflozin-metformin + Tenofovir df
Severity: Moderate
Dapagliflozin-metformin and Tenofovir df: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tenofovir disoproxil can cause renal tubular injury and reduce renal function, which may reduce metformin elimination and increase the risk of lactic acidosis. Tenofovir is also a substrate of renal transporters, though a major transporter-based interaction with metformin is not well established.
What this interaction means in plain words
Dapagliflozin-metformin and Tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Tenofovir-related renal impairment and possible competition at renal tubular transporters reduce metformin clearance.
What to do
Monitor eGFR and serum creatinine regularly and reduce or stop metformin if renal function declines. Counsel patients to report symptoms of lactic acidosis.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dapagliflozin-metformin
Frequently asked questions
Can I take Dapagliflozin-metformin with Tenofovir df?
MediHelp rates the interaction as moderate. Dapagliflozin-metformin and Tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tenofovir disoproxil can cause renal tubular injury and reduce renal function, which may reduce metformin elimination and increase the risk of lactic acidosis. Tenofovir is also a substrate of renal transporters, though a major transporter-based interaction with metformin is not well established.
How serious is the interaction between Dapagliflozin-metformin and Tenofovir df?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor eGFR and serum creatinine regularly and reduce or stop metformin if renal function declines. Counsel patients to report symptoms of lactic acidosis.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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