Drug interactions
Dapagliflozin-metformin + Thyroid desiccated
Severity: Moderate
Dapagliflozin-metformin and Thyroid desiccated: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thyroid hormones can increase glucose production and raise insulin requirements, which may reduce the effectiveness of metformin. Glycemic control can worsen when thyroid therapy is started or increased, and hypoglycemia may occur when it is withdrawn.
What this interaction means in plain words
Dapagliflozin-metformin and Thyroid desiccated can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Thyroid hormones increase hepatic glucose output and metabolic rate, opposing the antidiabetic effect.
What to do
Monitor blood glucose when thyroid therapy is started, changed or stopped, and adjust antidiabetic doses accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dapagliflozin-metformin
Frequently asked questions
Can I take Dapagliflozin-metformin with Thyroid desiccated?
MediHelp rates the interaction as moderate. Dapagliflozin-metformin and Thyroid desiccated can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thyroid hormones can increase glucose production and raise insulin requirements, which may reduce the effectiveness of metformin. Glycemic control can worsen when thyroid therapy is started or increased, and hypoglycemia may occur when it is withdrawn.
How serious is the interaction between Dapagliflozin-metformin and Thyroid desiccated?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when thyroid therapy is started, changed or stopped, and adjust antidiabetic doses accordingly.
What other medicines interact with Dapagliflozin-metformin?
MediHelp also lists interactions of Dapagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Dapagliflozin-metformin page.
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