Drug interactions
Daprodustat + Efavirenz
Severity: Minor
Daprodustat and Efavirenz: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Daprodustat is cleared mainly by CYP2C8, and drugs that inhibit this enzyme raise its exposure. Efavirenz is not a well-established CYP2C8 inhibitor, so the size of any effect is uncertain. Higher daprodustat exposure could increase hemoglobin overshoot and thromboembolic risk.
What this interaction means in plain words
Daprodustat and Efavirenz have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Daprodustat belongs to Endocrine; Efavirenz belongs to Anti Virals.
Why it happens
Possible weak CYP2C8 inhibition by efavirenz reducing daprodustat metabolism; not firmly established.
What to do
Monitor hemoglobin when efavirenz is started or stopped and adjust the daprodustat dose to hemoglobin response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Efavirenz
- Cobimetinib + Efavirenz Contraindicated
- Dienogest / estradiol valerate + Efavirenz Contraindicated
- Dihydroergotamine intranasal + Efavirenz Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Doravirine + Efavirenz Contraindicated
- Efavirenz + Elbasvir / grazoprevir Contraindicated
Other interactions of Daprodustat
- Daprodustat + Gemfibrozil Contraindicated
- Abiraterone + Daprodustat Moderate
- Alogliptin-pioglitazone + Daprodustat Moderate
- Carbamazepine + Daprodustat Moderate
- Clopidogrel + Daprodustat Moderate
- Daprodustat + Deferasirox Moderate
Frequently asked questions
Can I take Daprodustat with Efavirenz?
MediHelp rates the interaction as minor. Daprodustat and Efavirenz have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Daprodustat is cleared mainly by CYP2C8, and drugs that inhibit this enzyme raise its exposure. Efavirenz is not a well-established CYP2C8 inhibitor, so the size of any effect is uncertain. Higher daprodustat exposure could increase hemoglobin overshoot and thromboembolic risk.
How serious is the interaction between Daprodustat and Efavirenz?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor hemoglobin when efavirenz is started or stopped and adjust the daprodustat dose to hemoglobin response.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.
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