Drug interactions
Daprodustat + Griseofulvin
Severity: Minor
Daprodustat and Griseofulvin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Daprodustat is metabolized mainly by CYP2C8, and strong inhibitors markedly raise exposure. Griseofulvin is not an established CYP2C8 inhibitor; it is more commonly considered a weak CYP3A4 inducer, so the claimed interaction is doubtful.
What this interaction means in plain words
Daprodustat and Griseofulvin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Daprodustat belongs to Endocrine; Griseofulvin belongs to Anti Fungals.
Why it happens
Mechanism not established; CYP2C8 inhibition by griseofulvin is unproven.
What to do
Monitor hemoglobin as routinely required for daprodustat and adjust the dose to response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Griseofulvin
Other interactions of Daprodustat
- Daprodustat + Gemfibrozil Contraindicated
- Abiraterone + Daprodustat Moderate
- Alogliptin-pioglitazone + Daprodustat Moderate
- Carbamazepine + Daprodustat Moderate
- Clopidogrel + Daprodustat Moderate
- Daprodustat + Deferasirox Moderate
Frequently asked questions
Can I take Daprodustat with Griseofulvin?
MediHelp rates the interaction as minor. Daprodustat and Griseofulvin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Daprodustat is metabolized mainly by CYP2C8, and strong inhibitors markedly raise exposure. Griseofulvin is not an established CYP2C8 inhibitor; it is more commonly considered a weak CYP3A4 inducer, so the claimed interaction is doubtful.
How serious is the interaction between Daprodustat and Griseofulvin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor hemoglobin as routinely required for daprodustat and adjust the dose to response.
What other medicines interact with Griseofulvin?
MediHelp also lists interactions of Griseofulvin with, for example, Cyclosporine, Cyclosporin, Desogestrel-ethinyl estradiol. The full list is on the Griseofulvin page.
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