Drug interactions
Daprodustat + Metformin-pioglitazone
Severity: Minor
Daprodustat and Metformin-pioglitazone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Daprodustat is metabolized by CYP2C8, and inhibitors of this enzyme increase its exposure. Pioglitazone is a weak CYP2C8 inhibitor, so the effect is likely small, but higher daprodustat levels could cause excessive hemoglobin rise and thrombotic events.
What this interaction means in plain words
Daprodustat and Metformin-pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Daprodustat belongs to Endocrine; Metformin-pioglitazone belongs to Endocrine.
Why it happens
Inhibition of CYP2C8-mediated daprodustat metabolism by pioglitazone.
What to do
Monitor hemoglobin and adjust the daprodustat dose when pioglitazone is started or stopped.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-pioglitazone
Other interactions of Daprodustat
- Daprodustat + Gemfibrozil Contraindicated
- Abiraterone + Daprodustat Moderate
- Alogliptin-pioglitazone + Daprodustat Moderate
- Carbamazepine + Daprodustat Moderate
- Clopidogrel + Daprodustat Moderate
- Daprodustat + Deferasirox Moderate
Frequently asked questions
Can I take Daprodustat with Metformin-pioglitazone?
MediHelp rates the interaction as minor. Daprodustat and Metformin-pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Daprodustat is metabolized by CYP2C8, and inhibitors of this enzyme increase its exposure. Pioglitazone is a weak CYP2C8 inhibitor, so the effect is likely small, but higher daprodustat levels could cause excessive hemoglobin rise and thrombotic events.
How serious is the interaction between Daprodustat and Metformin-pioglitazone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor hemoglobin and adjust the daprodustat dose when pioglitazone is started or stopped.
What other medicines interact with Metformin-pioglitazone?
MediHelp also lists interactions of Metformin-pioglitazone with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin-pioglitazone page.
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