Drug interactions
Daprodustat + Pioglitazone
Severity: Moderate
Daprodustat and Pioglitazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pioglitazone is a moderate CYP2C8 inhibitor, and daprodustat is cleared mainly by CYP2C8. Coadministration raises daprodustat exposure, which can lead to excessive erythropoietic response and a higher risk of adverse effects such as thrombotic events and hypertension.
What this interaction means in plain words
Daprodustat and Pioglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Daprodustat belongs to Endocrine; Pioglitazone belongs to Endocrine.
Why it happens
Inhibition of CYP2C8-mediated metabolism of daprodustat reduces its clearance.
What to do
Halve the daprodustat starting dose when a moderate CYP2C8 inhibitor is used, unless the starting dose is already 1 mg. Monitor hemoglobin and adjust the daprodustat dose when pioglitazone is started or stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pioglitazone
Other interactions of Daprodustat
- Daprodustat + Gemfibrozil Contraindicated
- Abiraterone + Daprodustat Moderate
- Alogliptin-pioglitazone + Daprodustat Moderate
- Carbamazepine + Daprodustat Moderate
- Clopidogrel + Daprodustat Moderate
- Daprodustat + Deferasirox Moderate
Frequently asked questions
Can I take Daprodustat with Pioglitazone?
MediHelp rates the interaction as moderate. Daprodustat and Pioglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pioglitazone is a moderate CYP2C8 inhibitor, and daprodustat is cleared mainly by CYP2C8. Coadministration raises daprodustat exposure, which can lead to excessive erythropoietic response and a higher risk of adverse effects such as thrombotic events and hypertension.
How serious is the interaction between Daprodustat and Pioglitazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Halve the daprodustat starting dose when a moderate CYP2C8 inhibitor is used, unless the starting dose is already 1 mg. Monitor hemoglobin and adjust the daprodustat dose when pioglitazone is started or stopped.
What other medicines interact with Pioglitazone?
MediHelp also lists interactions of Pioglitazone with, for example, Insulin aspart-insulin aspart protamine, Insulin aspart, Insulin degludec-insulin aspart. The full list is on the Pioglitazone page.
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