Drug interactions
Daprodustat + Tamoxifen
Severity: Moderate
Daprodustat and Tamoxifen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tamoxifen may inhibit CYP2C8, the main enzyme clearing daprodustat, raising daprodustat exposure. This could lead to excessive hemoglobin rise and associated thrombotic or cardiovascular risk.
What this interaction means in plain words
Daprodustat and Tamoxifen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Daprodustat belongs to Endocrine; Tamoxifen belongs to Endocrine.
Why it happens
CYP2C8 inhibition reduces daprodustat metabolism.
What to do
Monitor hemoglobin closely and adjust the daprodustat dose, following labeling for moderate CYP2C8 inhibitors, when starting or stopping tamoxifen.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tamoxifen
- Amiodarone + Tamoxifen Major
- Anastrozole + Tamoxifen Major
- Bupropion + Tamoxifen Major
- Carbamazepine + Tamoxifen Major
- Cinacalcet + Tamoxifen Major
- Dacomitinib + Tamoxifen Major
Other interactions of Daprodustat
- Daprodustat + Gemfibrozil Contraindicated
- Abiraterone + Daprodustat Moderate
- Alogliptin-pioglitazone + Daprodustat Moderate
- Carbamazepine + Daprodustat Moderate
- Clopidogrel + Daprodustat Moderate
- Daprodustat + Deferasirox Moderate
Frequently asked questions
Can I take Daprodustat with Tamoxifen?
MediHelp rates the interaction as moderate. Daprodustat and Tamoxifen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tamoxifen may inhibit CYP2C8, the main enzyme clearing daprodustat, raising daprodustat exposure. This could lead to excessive hemoglobin rise and associated thrombotic or cardiovascular risk.
How serious is the interaction between Daprodustat and Tamoxifen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor hemoglobin closely and adjust the daprodustat dose, following labeling for moderate CYP2C8 inhibitors, when starting or stopping tamoxifen.
What other medicines interact with Tamoxifen?
MediHelp also lists interactions of Tamoxifen with, for example, Amiodarone, Anastrozole, Bupropion. The full list is on the Tamoxifen page.
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