Drug interactions
Darifenacin + Desipramine
Severity: Moderate
Darifenacin and Desipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Desipramine is metabolized by CYP2D6, which darifenacin inhibits moderately, so desipramine levels may rise. Both drugs also have anticholinergic effects that add together. This can increase tricyclic toxicity and anticholinergic adverse effects.
What this interaction means in plain words
Darifenacin and Desipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darifenacin belongs to Genitourinary; Desipramine belongs to Central Nervous System.
Why it happens
Darifenacin inhibits CYP2D6, reducing desipramine clearance, plus additive antimuscarinic effects.
What to do
Monitor for anticholinergic effects and tricyclic toxicity such as tachycardia or QRS widening. Consider checking desipramine levels or reducing its dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Darifenacin
Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Darifenacin with Desipramine?
MediHelp rates the interaction as moderate. Darifenacin and Desipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Desipramine is metabolized by CYP2D6, which darifenacin inhibits moderately, so desipramine levels may rise. Both drugs also have anticholinergic effects that add together. This can increase tricyclic toxicity and anticholinergic adverse effects.
How serious is the interaction between Darifenacin and Desipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects and tricyclic toxicity such as tachycardia or QRS widening. Consider checking desipramine levels or reducing its dose.
What other medicines interact with Darifenacin?
MediHelp also lists interactions of Darifenacin with, for example, Atazanavir, Bethanechol, Clarithromycin. The full list is on the Darifenacin page.
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