Drug interactions
Darifenacin + Dextromethorphan
Severity: Minor
Darifenacin and Dextromethorphan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darifenacin is a weak inhibitor of CYP2D6 and may modestly raise dextromethorphan exposure. The clinical effect is expected to be small, with possible mild increases in dizziness or drowsiness.
What this interaction means in plain words
Darifenacin and Dextromethorphan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Darifenacin belongs to Genitourinary; Dextromethorphan belongs to Respiratory.
Why it happens
Weak inhibition of CYP2D6-mediated O-demethylation of dextromethorphan by darifenacin.
What to do
No routine adjustment is needed; counsel the patient to report excess drowsiness or dizziness if dextromethorphan is used regularly.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dextromethorphan
- Dextromethorphan + Isocarboxazid Contraindicated
- Dextromethorphan + Linezolid Contraindicated
- Dextromethorphan + Phenelzine Contraindicated
- Dextromethorphan + Rasagiline Contraindicated
- Dextromethorphan + Safinamide Contraindicated
- Dextromethorphan + Selegiline Contraindicated
Other interactions of Darifenacin
Frequently asked questions
Can I take Darifenacin with Dextromethorphan?
MediHelp rates the interaction as minor. Darifenacin and Dextromethorphan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Darifenacin is a weak inhibitor of CYP2D6 and may modestly raise dextromethorphan exposure. The clinical effect is expected to be small, with possible mild increases in dizziness or drowsiness.
How serious is the interaction between Darifenacin and Dextromethorphan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; counsel the patient to report excess drowsiness or dizziness if dextromethorphan is used regularly.
What other medicines interact with Dextromethorphan?
MediHelp also lists interactions of Dextromethorphan with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Dextromethorphan page.
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