Drug interactions
dextromethorphan + linezolid
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
High risk of serotonin syndrome when MAO-inhibiting antibiotic is used with serotonergic antitussive.
Mechanism of action
Pharmacodynamic: Linezolid’s MAO inhibition plus dextromethorphan’s serotonergic activity → excess serotonergic neurotransmission.
Clinical management
Do not coadminister. Use a nonserotonergic antitussive (e.g., benzonatate) during linezolid therapy. Resume dextromethorphan ≥24 h after the last linezolid dose if needed.
Drug reference
References
- Zyvox (linezolid) Prescribing Information — FDA Label
- Dextromethorphan Drug Facts (OTC) — MAOI warning — FDA Label
- Dextromethorphan: Drug Interactions — Lexicomp
Frequently asked questions
Can I take dextromethorphan with linezolid?
The interaction is rated: Contraindicated. High risk of serotonin syndrome when MAO-inhibiting antibiotic is used with serotonergic antitussive.
How serious is the interaction between dextromethorphan and linezolid?
The interaction is rated: Contraindicated. Evidence level: High.
How is the interaction between dextromethorphan and linezolid managed?
Do not coadminister. Use a nonserotonergic antitussive (e.g., benzonatate) during linezolid therapy. Resume dextromethorphan ≥24 h after the last linezolid dose if needed.
Why do dextromethorphan and linezolid interact?
Pharmacodynamic: Linezolid’s MAO inhibition plus dextromethorphan’s serotonergic activity → excess serotonergic neurotransmission.
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