Drug interactions
dextromethorphan + selegiline
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Serotonin syndrome risk; generally contraindicated.
Mechanism of action
MAO inhibition + serotonergic antitussive.
Clinical management
Avoid combination.
Drug reference
References
- Selegiline – Label — FDA Label
- Dextromethorphan + MAOI — PubMed
Frequently asked questions
Can I take dextromethorphan with selegiline?
The interaction is rated: Contraindicated. Serotonin syndrome risk; generally contraindicated.
How serious is the interaction between dextromethorphan and selegiline?
The interaction is rated: Contraindicated. Evidence level: High.
How is the interaction between dextromethorphan and selegiline managed?
Avoid combination.
Why do dextromethorphan and selegiline interact?
MAO inhibition + serotonergic antitussive.
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