Drug interactions
Darifenacin + Dutasteride-tamsulosin
Severity: Minor
Darifenacin and Dutasteride-tamsulosin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darifenacin is a moderate CYP2D6 inhibitor in vitro, but the clinical effect on tamsulosin exposure is small. The combination is sometimes used for mixed urinary symptoms, and the practical concern is mainly urinary retention rather than tamsulosin toxicity.
What this interaction means in plain words
Darifenacin and Dutasteride-tamsulosin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Darifenacin belongs to Genitourinary; Dutasteride-tamsulosin belongs to Genitourinary.
Why it happens
Possible weak CYP2D6 inhibition by darifenacin; the antimuscarinic and alpha-blocker effects are otherwise pharmacodynamically distinct.
What to do
No dose adjustment is needed. Monitor for urinary retention and orthostatic symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dutasteride-tamsulosin
Other interactions of Darifenacin
Frequently asked questions
Can I take Darifenacin with Dutasteride-tamsulosin?
MediHelp rates the interaction as minor. Darifenacin and Dutasteride-tamsulosin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Darifenacin is a moderate CYP2D6 inhibitor in vitro, but the clinical effect on tamsulosin exposure is small. The combination is sometimes used for mixed urinary symptoms, and the practical concern is mainly urinary retention rather than tamsulosin toxicity.
How serious is the interaction between Darifenacin and Dutasteride-tamsulosin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Monitor for urinary retention and orthostatic symptoms.
What other medicines interact with Dutasteride-tamsulosin?
MediHelp also lists interactions of Dutasteride-tamsulosin with, for example, Alfuzosin, Amifostine, Atazanavir. The full list is on the Dutasteride-tamsulosin page.
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