Drug interactions
Darifenacin + Duvelisib
Severity: Moderate
Darifenacin and Duvelisib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Duvelisib inhibits CYP3A4, which is a main route of darifenacin metabolism, so darifenacin exposure may rise. This may increase anticholinergic adverse effects.
What this interaction means in plain words
Darifenacin and Duvelisib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darifenacin belongs to Genitourinary; Duvelisib belongs to Oncology.
Why it happens
CYP3A4 inhibition by duvelisib reduces darifenacin clearance.
What to do
Monitor for anticholinergic toxicity and consider reducing the darifenacin dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Darifenacin
Other interactions of Duvelisib
- Duvelisib + Ergotamine Contraindicated
- Alfuzosin + Duvelisib Major
- Apalutamide + Duvelisib Major
- Avanafil + Duvelisib Major
- Carbamazepine + Duvelisib Major
- Chloramphenicol + Duvelisib Major
Frequently asked questions
Can I take Darifenacin with Duvelisib?
MediHelp rates the interaction as moderate. Darifenacin and Duvelisib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Duvelisib inhibits CYP3A4, which is a main route of darifenacin metabolism, so darifenacin exposure may rise. This may increase anticholinergic adverse effects.
How serious is the interaction between Darifenacin and Duvelisib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity and consider reducing the darifenacin dose.
What other medicines interact with Darifenacin?
MediHelp also lists interactions of Darifenacin with, for example, Atazanavir, Bethanechol, Clarithromycin. The full list is on the Darifenacin page.
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