Drug interactions
Darifenacin + Hydrocodone
Severity: Minor
Darifenacin and Hydrocodone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darifenacin inhibits CYP2D6, which converts hydrocodone to hydromorphone, so analgesia may be reduced slightly. Both drugs can also cause constipation and urinary retention.
What this interaction means in plain words
Darifenacin and Hydrocodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Darifenacin belongs to Genitourinary; Hydrocodone belongs to Musculoskeletal.
Why it happens
CYP2D6 inhibition reduces the formation of active hydromorphone, with additive antimuscarinic effects on bowel and bladder.
What to do
Monitor analgesic response and bowel and bladder function. Adjust the opioid dose to effect.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Darifenacin
Other interactions of Hydrocodone
- Alvimopan + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Hydrocodone + Isocarboxazid Contraindicated
- Hydrocodone + Olanzapine / samidorphan Contraindicated
- Hydrocodone + Phenelzine Contraindicated
- Alfentanil + Hydrocodone Major
Frequently asked questions
Can I take Darifenacin with Hydrocodone?
MediHelp rates the interaction as minor. Darifenacin and Hydrocodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Darifenacin inhibits CYP2D6, which converts hydrocodone to hydromorphone, so analgesia may be reduced slightly. Both drugs can also cause constipation and urinary retention.
How serious is the interaction between Darifenacin and Hydrocodone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor analgesic response and bowel and bladder function. Adjust the opioid dose to effect.
What other medicines interact with Darifenacin?
MediHelp also lists interactions of Darifenacin with, for example, Atazanavir, Bethanechol, Clarithromycin. The full list is on the Darifenacin page.
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