Drug interactions
Darifenacin + Isavuconazonium
Severity: Minor
Darifenacin and Isavuconazonium: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isavuconazole is a moderate CYP3A4 inhibitor and a substrate of CYP3A4, but darifenacin is a weak inhibitor, so any increase in isavuconazole exposure should be minor. The more relevant effect is the reverse, with isavuconazole raising darifenacin levels.
What this interaction means in plain words
Darifenacin and Isavuconazonium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Darifenacin belongs to Genitourinary; Isavuconazonium belongs to Anti Fungals.
Why it happens
Weak CYP3A4 competition; isavuconazole inhibits CYP3A4 and may raise darifenacin exposure.
What to do
Monitor for darifenacin adverse effects such as dry mouth and constipation. Dose adjustment of isavuconazonium is not normally needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Darifenacin
Other interactions of Isavuconazonium
- Amobarbital + Isavuconazonium Contraindicated
- Apalutamide + Isavuconazonium Contraindicated
- Carbamazepine + Isavuconazonium Contraindicated
- Cisapride + Isavuconazonium Contraindicated
- Efavirenz + Isavuconazonium Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
Frequently asked questions
Can I take Darifenacin with Isavuconazonium?
MediHelp rates the interaction as minor. Darifenacin and Isavuconazonium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Isavuconazole is a moderate CYP3A4 inhibitor and a substrate of CYP3A4, but darifenacin is a weak inhibitor, so any increase in isavuconazole exposure should be minor. The more relevant effect is the reverse, with isavuconazole raising darifenacin levels.
How serious is the interaction between Darifenacin and Isavuconazonium?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for darifenacin adverse effects such as dry mouth and constipation. Dose adjustment of isavuconazonium is not normally needed.
What other medicines interact with Darifenacin?
MediHelp also lists interactions of Darifenacin with, for example, Atazanavir, Bethanechol, Clarithromycin. The full list is on the Darifenacin page.
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