Drug interactions
Darifenacin + Lemborexant
Severity: Moderate
Darifenacin and Lemborexant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darifenacin is a weak CYP3A4 inhibitor and may raise lemborexant exposure, increasing next-day sedation and somnolence.
What this interaction means in plain words
Darifenacin and Lemborexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darifenacin belongs to Genitourinary; Lemborexant belongs to Central Nervous System.
Why it happens
Weak CYP3A4 inhibition by darifenacin decreases lemborexant clearance.
What to do
Limit lemborexant to the reduced maximum dose recommended with weak CYP3A4 inhibitors and monitor for daytime drowsiness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Darifenacin
Other interactions of Lemborexant
Frequently asked questions
Can I take Darifenacin with Lemborexant?
MediHelp rates the interaction as moderate. Darifenacin and Lemborexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Darifenacin is a weak CYP3A4 inhibitor and may raise lemborexant exposure, increasing next-day sedation and somnolence.
How serious is the interaction between Darifenacin and Lemborexant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit lemborexant to the reduced maximum dose recommended with weak CYP3A4 inhibitors and monitor for daytime drowsiness.
What other medicines interact with Darifenacin?
MediHelp also lists interactions of Darifenacin with, for example, Atazanavir, Bethanechol, Clarithromycin. The full list is on the Darifenacin page.
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