Drug interactions
Darifenacin + Maprotiline
Severity: Moderate
Darifenacin and Maprotiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Maprotiline has anticholinergic activity and is metabolised by CYP2D6, so darifenacin may add to anticholinergic burden and modestly raise maprotiline levels. Maprotiline also lowers the seizure threshold, making toxicity more relevant.
What this interaction means in plain words
Darifenacin and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darifenacin belongs to Genitourinary; Maprotiline belongs to Central Nervous System.
Why it happens
Additive antimuscarinic effects with possible CYP2D6 inhibition by darifenacin.
What to do
Monitor for anticholinergic effects, confusion and urinary retention. Consider a lower maprotiline dose or a non-antimuscarinic bladder agent.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Darifenacin
Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Frequently asked questions
Can I take Darifenacin with Maprotiline?
MediHelp rates the interaction as moderate. Darifenacin and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Maprotiline has anticholinergic activity and is metabolised by CYP2D6, so darifenacin may add to anticholinergic burden and modestly raise maprotiline levels. Maprotiline also lowers the seizure threshold, making toxicity more relevant.
How serious is the interaction between Darifenacin and Maprotiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects, confusion and urinary retention. Consider a lower maprotiline dose or a non-antimuscarinic bladder agent.
What other medicines interact with Darifenacin?
MediHelp also lists interactions of Darifenacin with, for example, Atazanavir, Bethanechol, Clarithromycin. The full list is on the Darifenacin page.
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