Drug interactions
Darifenacin + Mitotane
Severity: Moderate
Darifenacin and Mitotane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mitotane strongly induces CYP3A4 and can substantially lower darifenacin concentrations. The result may be loss of control of overactive bladder symptoms, and the induction can persist for weeks after mitotane is stopped.
What this interaction means in plain words
Darifenacin and Mitotane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darifenacin belongs to Genitourinary; Mitotane belongs to Oncology.
Why it happens
Induction of CYP3A4 by mitotane increases darifenacin metabolism and lowers its plasma levels.
What to do
Monitor for reduced symptom control and consider a higher darifenacin dose within the labeled range or an alternative agent. Reassess the dose when mitotane is discontinued.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Darifenacin
Other interactions of Mitotane
- Doravirine + Mitotane Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Lorlatinib + Mitotane Contraindicated
- Abiraterone + Mitotane Major
- Apixaban + Mitotane Major
- Aprepitant + Mitotane Major
Frequently asked questions
Can I take Darifenacin with Mitotane?
MediHelp rates the interaction as moderate. Darifenacin and Mitotane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mitotane strongly induces CYP3A4 and can substantially lower darifenacin concentrations. The result may be loss of control of overactive bladder symptoms, and the induction can persist for weeks after mitotane is stopped.
How serious is the interaction between Darifenacin and Mitotane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced symptom control and consider a higher darifenacin dose within the labeled range or an alternative agent. Reassess the dose when mitotane is discontinued.
What other medicines interact with Darifenacin?
MediHelp also lists interactions of Darifenacin with, for example, Atazanavir, Bethanechol, Clarithromycin. The full list is on the Darifenacin page.
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