Drug interactions
Darifenacin + Nebivolol
Severity: Moderate
Darifenacin and Nebivolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nebivolol is metabolized by CYP2D6, and darifenacin is a moderate CYP2D6 inhibitor, so nebivolol exposure may rise. This can deepen bradycardia and hypotension, particularly in patients who are already CYP2D6 poor metabolizers.
What this interaction means in plain words
Darifenacin and Nebivolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darifenacin belongs to Genitourinary; Nebivolol belongs to Cardiovascular.
Why it happens
Darifenacin inhibits CYP2D6, reducing the metabolic clearance of nebivolol.
What to do
Monitor heart rate and blood pressure when starting or stopping darifenacin. Reduce the nebivolol dose if bradycardia or hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Darifenacin
Other interactions of Nebivolol
- Acebutolol + Nebivolol Major
- Aldesleukin + Nebivolol Major
- Amiodarone + Nebivolol Major
- Atenolol-chlorthalidone + Nebivolol Major
- Atenolol + Nebivolol Major
- Betaxolol + Nebivolol Major
Frequently asked questions
Can I take Darifenacin with Nebivolol?
MediHelp rates the interaction as moderate. Darifenacin and Nebivolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nebivolol is metabolized by CYP2D6, and darifenacin is a moderate CYP2D6 inhibitor, so nebivolol exposure may rise. This can deepen bradycardia and hypotension, particularly in patients who are already CYP2D6 poor metabolizers.
How serious is the interaction between Darifenacin and Nebivolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure when starting or stopping darifenacin. Reduce the nebivolol dose if bradycardia or hypotension develops.
What other medicines interact with Darifenacin?
MediHelp also lists interactions of Darifenacin with, for example, Atazanavir, Bethanechol, Clarithromycin. The full list is on the Darifenacin page.
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