Drug interactions
Darifenacin + Oxymorphone
Severity: Minor
Darifenacin and Oxymorphone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxymorphone is cleared mainly by glucuronidation rather than CYP2D6, so a pharmacokinetic interaction with darifenacin is not expected. Additive constipation and urinary retention are possible.
What this interaction means in plain words
Darifenacin and Oxymorphone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Darifenacin belongs to Genitourinary; Oxymorphone belongs to Musculoskeletal.
Why it happens
No relevant CYP2D6 dependence; additive anticholinergic and opioid effects on smooth muscle.
What to do
No dose adjustment is needed. Monitor bowel and bladder function.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Darifenacin
Other interactions of Oxymorphone
- Alvimopan + Oxymorphone Contraindicated
- Ethanol + Oxymorphone Contraindicated
- Isocarboxazid + Oxymorphone Contraindicated
- Olanzapine / samidorphan + Oxymorphone Contraindicated
- Oxymorphone + Phenelzine Contraindicated
- Oxymorphone + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Darifenacin with Oxymorphone?
MediHelp rates the interaction as minor. Darifenacin and Oxymorphone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oxymorphone is cleared mainly by glucuronidation rather than CYP2D6, so a pharmacokinetic interaction with darifenacin is not expected. Additive constipation and urinary retention are possible.
How serious is the interaction between Darifenacin and Oxymorphone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Monitor bowel and bladder function.
What other medicines interact with Darifenacin?
MediHelp also lists interactions of Darifenacin with, for example, Atazanavir, Bethanechol, Clarithromycin. The full list is on the Darifenacin page.
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