Drug interactions
Darifenacin + Pilocarpine
Severity: Moderate
Darifenacin and Pilocarpine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pilocarpine is a muscarinic agonist while darifenacin is an antagonist, so they oppose each other. Both may lose effect, with reduced saliva stimulation and persistent bladder symptoms.
What this interaction means in plain words
Darifenacin and Pilocarpine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darifenacin belongs to Genitourinary; Pilocarpine belongs to Miscellaneous.
Why it happens
Pharmacodynamic antagonism at muscarinic receptors.
What to do
Monitor for loss of pilocarpine's effect on dry mouth and loss of darifenacin's effect on bladder symptoms. Reassess whether both drugs are needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Darifenacin
Other interactions of Pilocarpine
- Amitriptyline + Pilocarpine Moderate
- Atenolol-chlorthalidone + Pilocarpine Moderate
- Atenolol + Pilocarpine Moderate
- Atropine + Pilocarpine Moderate
- Betaxolol + Pilocarpine Moderate
- Bethanechol + Pilocarpine Moderate
Frequently asked questions
Can I take Darifenacin with Pilocarpine?
MediHelp rates the interaction as moderate. Darifenacin and Pilocarpine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pilocarpine is a muscarinic agonist while darifenacin is an antagonist, so they oppose each other. Both may lose effect, with reduced saliva stimulation and persistent bladder symptoms.
How serious is the interaction between Darifenacin and Pilocarpine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of pilocarpine's effect on dry mouth and loss of darifenacin's effect on bladder symptoms. Reassess whether both drugs are needed.
What other medicines interact with Darifenacin?
MediHelp also lists interactions of Darifenacin with, for example, Atazanavir, Bethanechol, Clarithromycin. The full list is on the Darifenacin page.
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