Drug interactions
Darifenacin + Propafenone
Severity: Moderate
Darifenacin and Propafenone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propafenone is metabolized by CYP2D6, and darifenacin may raise its levels, increasing the risk of conduction delay, bradycardia, and proarrhythmia. The effect is greater in patients with reduced CYP2D6 activity.
What this interaction means in plain words
Darifenacin and Propafenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darifenacin belongs to Genitourinary; Propafenone belongs to Cardiovascular.
Why it happens
Darifenacin inhibits CYP2D6, reducing propafenone clearance.
What to do
Monitor ECG and heart rate when starting darifenacin, and lower the propafenone dose if QRS widening or bradycardia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Darifenacin
Other interactions of Propafenone
- Dofetilide + Propafenone Contraindicated
- Dronedarone + Propafenone Contraindicated
- Nilotinib + Propafenone Contraindicated
- Nirmatrelvir / ritonavir + Propafenone Contraindicated
- Nirmatrelvir + Propafenone Contraindicated
- Pimozide + Propafenone Contraindicated
Frequently asked questions
Can I take Darifenacin with Propafenone?
MediHelp rates the interaction as moderate. Darifenacin and Propafenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Propafenone is metabolized by CYP2D6, and darifenacin may raise its levels, increasing the risk of conduction delay, bradycardia, and proarrhythmia. The effect is greater in patients with reduced CYP2D6 activity.
How serious is the interaction between Darifenacin and Propafenone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and heart rate when starting darifenacin, and lower the propafenone dose if QRS widening or bradycardia occurs.
What other medicines interact with Darifenacin?
MediHelp also lists interactions of Darifenacin with, for example, Atazanavir, Bethanechol, Clarithromycin. The full list is on the Darifenacin page.
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