Drug interactions
Darifenacin + Rifapentine
Severity: Moderate
Darifenacin and Rifapentine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifapentine induces CYP3A4 and can lower darifenacin concentrations, which may lead to loss of efficacy.
What this interaction means in plain words
Darifenacin and Rifapentine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darifenacin belongs to Genitourinary; Rifapentine belongs to Anti Bacterial.
Why it happens
Induction of CYP3A4 by rifapentine increases darifenacin metabolism.
What to do
Monitor symptom control and adjust the darifenacin dose or use an alternative agent if efficacy is lost. Reassess after rifapentine is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Darifenacin
Other interactions of Rifapentine
- Ledipasvir-sofosbuvir + Rifapentine Contraindicated
- Lorlatinib + Rifapentine Contraindicated
- Lurasidone + Rifapentine Contraindicated
- Ranolazine + Rifapentine Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Frequently asked questions
Can I take Darifenacin with Rifapentine?
MediHelp rates the interaction as moderate. Darifenacin and Rifapentine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifapentine induces CYP3A4 and can lower darifenacin concentrations, which may lead to loss of efficacy.
How serious is the interaction between Darifenacin and Rifapentine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor symptom control and adjust the darifenacin dose or use an alternative agent if efficacy is lost. Reassess after rifapentine is stopped.
What other medicines interact with Darifenacin?
MediHelp also lists interactions of Darifenacin with, for example, Atazanavir, Bethanechol, Clarithromycin. The full list is on the Darifenacin page.
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