Drug interactions
Rifapentine + Sofosbuvir-velpatasvir-voxilaprevir
Severity: Contraindicated
Rifapentine and Sofosbuvir-velpatasvir-voxilaprevir: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifapentine is an inducer of CYP enzymes and P-glycoprotein and can markedly lower plasma concentrations of sofosbuvir, velpatasvir and voxilaprevir. This may lead to loss of antiviral activity and failure to achieve sustained virologic response.
What this interaction means in plain words
Rifapentine and Sofosbuvir-velpatasvir-voxilaprevir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Rifapentine belongs to Anti Bacterial; Sofosbuvir-velpatasvir-voxilaprevir belongs to Anti Virals.
Why it happens
Induction of intestinal and hepatic CYP3A4 and P-glycoprotein by rifapentine increases clearance and reduces absorption of the HCV agents.
What to do
Do not coadminister; rifamycin inducers are not recommended with this regimen. Choose an alternative tuberculosis regimen or delay HCV therapy until rifapentine is completed.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Sofosbuvir-velpatasvir-voxilaprevir
- Fosphenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Phenobarbital + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Phenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Rifampin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Sofosbuvir-velpatasvir-voxilaprevir + St john's wort Contraindicated
Other interactions of Rifapentine
- Ledipasvir-sofosbuvir + Rifapentine Contraindicated
- Lorlatinib + Rifapentine Contraindicated
- Lurasidone + Rifapentine Contraindicated
- Ranolazine + Rifapentine Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir Contraindicated
- Abiraterone + Rifapentine Major
Frequently asked questions
Can I take Rifapentine with Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp rates the interaction as contraindicated. Rifapentine and Sofosbuvir-velpatasvir-voxilaprevir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Rifapentine is an inducer of CYP enzymes and P-glycoprotein and can markedly lower plasma concentrations of sofosbuvir, velpatasvir and voxilaprevir. This may lead to loss of antiviral activity and failure to achieve sustained virologic response.
How serious is the interaction between Rifapentine and Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; rifamycin inducers are not recommended with this regimen. Choose an alternative tuberculosis regimen or delay HCV therapy until rifapentine is completed.
What other medicines interact with Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp also lists interactions of Sofosbuvir-velpatasvir-voxilaprevir with, for example, Fosphenytoin, Phenobarbital, Phenytoin. The full list is on the Sofosbuvir-velpatasvir-voxilaprevir page.
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