Drug interactions
Darifenacin + Simvastatin
Severity: Minor
Darifenacin and Simvastatin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darifenacin is not a significant CYP3A4 inhibitor, so a clinically relevant rise in simvastatin exposure is not expected.
What this interaction means in plain words
Darifenacin and Simvastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Darifenacin belongs to Genitourinary; Simvastatin belongs to Cardiovascular.
Why it happens
No established mechanism; darifenacin does not meaningfully inhibit CYP3A4.
What to do
No adjustment is needed; advise patients to report unexplained muscle symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Darifenacin
Other interactions of Simvastatin
- Atazanavir + Simvastatin Contraindicated
- Clarithromycin + Simvastatin Contraindicated
- Cobicistat + Simvastatin Contraindicated
- Cyclosporine + Simvastatin Contraindicated
- Cyclosporin + Simvastatin Contraindicated
- Danazol + Simvastatin Contraindicated
Frequently asked questions
Can I take Darifenacin with Simvastatin?
MediHelp rates the interaction as minor. Darifenacin and Simvastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Darifenacin is not a significant CYP3A4 inhibitor, so a clinically relevant rise in simvastatin exposure is not expected.
How serious is the interaction between Darifenacin and Simvastatin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment is needed; advise patients to report unexplained muscle symptoms.
What other medicines interact with Darifenacin?
MediHelp also lists interactions of Darifenacin with, for example, Atazanavir, Bethanechol, Clarithromycin. The full list is on the Darifenacin page.
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