Drug interactions
Darifenacin + Tamsulosin
Severity: Minor
Darifenacin and Tamsulosin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darifenacin is a moderate CYP2D6 inhibitor and may increase tamsulosin exposure. This could increase dizziness and orthostatic hypotension, though the effect is usually modest.
What this interaction means in plain words
Darifenacin and Tamsulosin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Darifenacin belongs to Genitourinary; Tamsulosin belongs to Genitourinary.
Why it happens
CYP2D6 inhibition by darifenacin reduces tamsulosin metabolism.
What to do
Monitor for orthostatic symptoms when combining. No routine dose change is required.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tamsulosin
- Alfuzosin + Tamsulosin Major
- Avanafil + Tamsulosin Major
- Ceritinib + Tamsulosin Major
- Clarithromycin + Tamsulosin Major
- Cobicistat + Tamsulosin Major
- Doxazosin + Tamsulosin Major
Other interactions of Darifenacin
Frequently asked questions
Can I take Darifenacin with Tamsulosin?
MediHelp rates the interaction as minor. Darifenacin and Tamsulosin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Darifenacin is a moderate CYP2D6 inhibitor and may increase tamsulosin exposure. This could increase dizziness and orthostatic hypotension, though the effect is usually modest.
How serious is the interaction between Darifenacin and Tamsulosin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for orthostatic symptoms when combining. No routine dose change is required.
What other medicines interact with Tamsulosin?
MediHelp also lists interactions of Tamsulosin with, for example, Alfuzosin, Avanafil, Ceritinib. The full list is on the Tamsulosin page.
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