Drug interactions
Avanafil + Tamsulosin
Severity: Major
Avanafil and Tamsulosin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a PDE5 inhibitor with an alpha-blocker can cause symptomatic postural hypotension, dizziness or syncope, especially at treatment initiation.
What this interaction means in plain words
Avanafil and Tamsulosin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Avanafil belongs to Genitourinary; Tamsulosin belongs to Genitourinary.
Why it happens
Additive vasodilation from alpha-1 blockade and PDE5 inhibition.
What to do
Begin avanafil at the lowest dose once the alpha-blocker dose is stable, and counsel about rising slowly. Monitor blood pressure.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Avanafil
- Amyl nitrite + Avanafil Contraindicated
- Atazanavir + Avanafil Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Avanafil + Conivaptan Contraindicated
- Avanafil + Darunavir Contraindicated
- Avanafil + Fosamprenavir Contraindicated
Other interactions of Tamsulosin
- Alfuzosin + Tamsulosin Major
- Ceritinib + Tamsulosin Major
- Clarithromycin + Tamsulosin Major
- Cobicistat + Tamsulosin Major
- Doxazosin + Tamsulosin Major
- Idelalisib + Tamsulosin Major
Frequently asked questions
Can I take Avanafil with Tamsulosin?
MediHelp rates the interaction as major. Avanafil and Tamsulosin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining a PDE5 inhibitor with an alpha-blocker can cause symptomatic postural hypotension, dizziness or syncope, especially at treatment initiation.
How serious is the interaction between Avanafil and Tamsulosin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Begin avanafil at the lowest dose once the alpha-blocker dose is stable, and counsel about rising slowly. Monitor blood pressure.
What other medicines interact with Avanafil?
MediHelp also lists interactions of Avanafil with, for example, Amyl nitrite, Atazanavir, Clarithromycin. The full list is on the Avanafil page.
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