Drug interactions
Ceritinib + Tamsulosin
Severity: Major
Ceritinib and Tamsulosin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ceritinib is a strong CYP3A4 and CYP2D6 inhibitor and may considerably raise tamsulosin levels. This can cause symptomatic hypotension and syncope.
What this interaction means in plain words
Ceritinib and Tamsulosin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ceritinib belongs to Oncology; Tamsulosin belongs to Genitourinary.
Why it happens
Inhibition of CYP3A4 and CYP2D6 metabolism of tamsulosin.
What to do
Avoid if possible and use an alternative therapy. If combined, start with low dose and monitor blood pressure and orthostatic symptoms.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Tamsulosin
- Alfuzosin + Tamsulosin Major
- Avanafil + Tamsulosin Major
- Clarithromycin + Tamsulosin Major
- Cobicistat + Tamsulosin Major
- Doxazosin + Tamsulosin Major
- Idelalisib + Tamsulosin Major
Other interactions of Ceritinib
- Ceritinib + Cisapride Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Ceritinib + Pimozide Contraindicated
- Ceritinib + Thioridazine Contraindicated
- Ceritinib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Ceritinib with Tamsulosin?
MediHelp rates the interaction as major. Ceritinib and Tamsulosin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ceritinib is a strong CYP3A4 and CYP2D6 inhibitor and may considerably raise tamsulosin levels. This can cause symptomatic hypotension and syncope.
How serious is the interaction between Ceritinib and Tamsulosin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible and use an alternative therapy. If combined, start with low dose and monitor blood pressure and orthostatic symptoms.
What other medicines interact with Tamsulosin?
MediHelp also lists interactions of Tamsulosin with, for example, Alfuzosin, Avanafil, Clarithromycin. The full list is on the Tamsulosin page.
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