Drug interactions
Darifenacin + Umeclidinium-vilanterol
Severity: Moderate
Darifenacin and Umeclidinium-vilanterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both umeclidinium and darifenacin are antimuscarinic agents, so combined use can add anticholinergic effects such as dry mouth, constipation, urinary retention and blurred vision. Systemic exposure from inhaled umeclidinium is low, so the effect is usually modest.
What this interaction means in plain words
Darifenacin and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darifenacin belongs to Genitourinary; Umeclidinium-vilanterol belongs to Respiratory.
Why it happens
Additive antimuscarinic pharmacodynamic effects.
What to do
Monitor for urinary retention, constipation, narrow-angle glaucoma symptoms and dry mouth. Reduce or stop one agent if anticholinergic effects become troublesome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Darifenacin and Umeclidinium-vilanterol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Umeclidinium-vilanterol
Other interactions of Darifenacin
Frequently asked questions
Can I take Darifenacin with Umeclidinium-vilanterol?
MediHelp rates the interaction as moderate. Darifenacin and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both umeclidinium and darifenacin are antimuscarinic agents, so combined use can add anticholinergic effects such as dry mouth, constipation, urinary retention and blurred vision. Systemic exposure from inhaled umeclidinium is low, so the effect is usually modest.
How serious is the interaction between Darifenacin and Umeclidinium-vilanterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for urinary retention, constipation, narrow-angle glaucoma symptoms and dry mouth. Reduce or stop one agent if anticholinergic effects become troublesome.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
