Drug interactions
Darifenacin + Vardenafil
Severity: Minor
Darifenacin and Vardenafil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darifenacin is a CYP2D6 substrate with only weak CYP3A4 inhibitory activity, so a meaningful increase in vardenafil exposure is not well established. No clear clinical interaction is expected.
What this interaction means in plain words
Darifenacin and Vardenafil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Darifenacin belongs to Genitourinary; Vardenafil belongs to Genitourinary.
Why it happens
Weak, unconfirmed CYP3A4 inhibition by darifenacin.
What to do
No dose adjustment is needed; monitor for vardenafil adverse effects such as headache or hypotension.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Vardenafil
- Amyl nitrite + Vardenafil Contraindicated
- Glyceryl trinitrate pr + Vardenafil Contraindicated
- Isosorbide dinitrate + Vardenafil Contraindicated
- Isosorbide mononitrate + Vardenafil Contraindicated
- Nicorandil + Vardenafil Contraindicated
- Nitroglycerin po + Vardenafil Contraindicated
Other interactions of Darifenacin
Frequently asked questions
Can I take Darifenacin with Vardenafil?
MediHelp rates the interaction as minor. Darifenacin and Vardenafil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Darifenacin is a CYP2D6 substrate with only weak CYP3A4 inhibitory activity, so a meaningful increase in vardenafil exposure is not well established. No clear clinical interaction is expected.
How serious is the interaction between Darifenacin and Vardenafil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; monitor for vardenafil adverse effects such as headache or hypotension.
What other medicines interact with Vardenafil?
MediHelp also lists interactions of Vardenafil with, for example, Amyl nitrite, Glyceryl trinitrate pr, Isosorbide dinitrate. The full list is on the Vardenafil page.
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