Drug interactions
Darifenacin + Verapamil
Severity: Moderate
Darifenacin and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil is a moderate CYP3A4 inhibitor and can raise darifenacin concentrations, increasing antimuscarinic adverse effects such as dry mouth and constipation. Darifenacin does not meaningfully affect verapamil exposure.
What this interaction means in plain words
Darifenacin and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darifenacin belongs to Genitourinary; Verapamil belongs to Cardiovascular.
Why it happens
Inhibition of CYP3A4-mediated darifenacin metabolism by verapamil.
What to do
Monitor for anticholinergic effects and keep darifenacin at the lowest effective dose, not exceeding the labeled limit with moderate CYP3A4 inhibitors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Darifenacin
Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Frequently asked questions
Can I take Darifenacin with Verapamil?
MediHelp rates the interaction as moderate. Darifenacin and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Verapamil is a moderate CYP3A4 inhibitor and can raise darifenacin concentrations, increasing antimuscarinic adverse effects such as dry mouth and constipation. Darifenacin does not meaningfully affect verapamil exposure.
How serious is the interaction between Darifenacin and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects and keep darifenacin at the lowest effective dose, not exceeding the labeled limit with moderate CYP3A4 inhibitors.
What other medicines interact with Darifenacin?
MediHelp also lists interactions of Darifenacin with, for example, Atazanavir, Bethanechol, Clarithromycin. The full list is on the Darifenacin page.
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