Drug interactions
Darifenacin + Voxelotor
Severity: Moderate
Darifenacin and Voxelotor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voxelotor inhibits CYP3A4 and may increase darifenacin exposure, leading to more anticholinergic adverse effects. The effect is expected to be moderate and is mainly a concern at higher darifenacin doses.
What this interaction means in plain words
Darifenacin and Voxelotor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darifenacin belongs to Genitourinary; Voxelotor belongs to Miscellaneous.
Why it happens
Voxelotor inhibits CYP3A4, reducing darifenacin clearance.
What to do
Monitor for anticholinergic toxicity and use the lowest effective darifenacin dose. Consider an alternative agent if adverse effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Darifenacin
Other interactions of Voxelotor
- Amobarbital + Voxelotor Major
- Apalutamide + Voxelotor Major
- Carbamazepine + Voxelotor Major
- Cyclosporin + Voxelotor Major
- Efavirenz + Voxelotor Major
- Enzalutamide + Voxelotor Major
Frequently asked questions
Can I take Darifenacin with Voxelotor?
MediHelp rates the interaction as moderate. Darifenacin and Voxelotor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voxelotor inhibits CYP3A4 and may increase darifenacin exposure, leading to more anticholinergic adverse effects. The effect is expected to be moderate and is mainly a concern at higher darifenacin doses.
How serious is the interaction between Darifenacin and Voxelotor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity and use the lowest effective darifenacin dose. Consider an alternative agent if adverse effects emerge.
What other medicines interact with Darifenacin?
MediHelp also lists interactions of Darifenacin with, for example, Atazanavir, Bethanechol, Clarithromycin. The full list is on the Darifenacin page.
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