Drug interactions
Darifenacin + Ziprasidone
Severity: Minor
Darifenacin and Ziprasidone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darifenacin may add modest anticholinergic effects to ziprasidone, and both can affect cardiac conduction in susceptible patients. Clinically important changes in ziprasidone levels are not established.
What this interaction means in plain words
Darifenacin and Ziprasidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Darifenacin belongs to Genitourinary; Ziprasidone belongs to Central Nervous System.
Why it happens
Additive anticholinergic effects; no established pharmacokinetic interaction.
What to do
Monitor for constipation, urinary retention and confusion; consider ECG monitoring if other QT-prolonging risks exist.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Darifenacin
Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Frequently asked questions
Can I take Darifenacin with Ziprasidone?
MediHelp rates the interaction as minor. Darifenacin and Ziprasidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Darifenacin may add modest anticholinergic effects to ziprasidone, and both can affect cardiac conduction in susceptible patients. Clinically important changes in ziprasidone levels are not established.
How serious is the interaction between Darifenacin and Ziprasidone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for constipation, urinary retention and confusion; consider ECG monitoring if other QT-prolonging risks exist.
What other medicines interact with Darifenacin?
MediHelp also lists interactions of Darifenacin with, for example, Atazanavir, Bethanechol, Clarithromycin. The full list is on the Darifenacin page.
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