Drug interactions
Darolutamide + Doxorubicin
Severity: Moderate
Darolutamide and Doxorubicin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darolutamide inhibits BCRP, an efflux transporter that handles doxorubicin, and may increase its systemic exposure. This could heighten myelosuppression and other dose-related toxicities.
What this interaction means in plain words
Darolutamide and Doxorubicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darolutamide belongs to Miscellaneous; Doxorubicin belongs to Oncology.
Why it happens
Darolutamide inhibits BCRP, reducing efflux of doxorubicin.
What to do
Monitor blood counts and cardiac status. Consider doxorubicin dose reduction if adverse reactions emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Doxorubicin
Other interactions of Darolutamide
Frequently asked questions
Can I take Darolutamide with Doxorubicin?
MediHelp rates the interaction as moderate. Darolutamide and Doxorubicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Darolutamide inhibits BCRP, an efflux transporter that handles doxorubicin, and may increase its systemic exposure. This could heighten myelosuppression and other dose-related toxicities.
How serious is the interaction between Darolutamide and Doxorubicin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and cardiac status. Consider doxorubicin dose reduction if adverse reactions emerge.
What other medicines interact with Doxorubicin?
MediHelp also lists interactions of Doxorubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cobicistat. The full list is on the Doxorubicin page.
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