Drug interactions
Darolutamide + Phenobarbitone
Severity: Major
Darolutamide and Phenobarbitone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenobarbitone is expected to lower darolutamide exposure and may reduce anticancer efficacy.
What this interaction means in plain words
Darolutamide and Phenobarbitone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Darolutamide belongs to Miscellaneous; Phenobarbitone belongs to Central Nervous System.
Why it happens
Induction of CYP3A4 and P-glycoprotein by phenobarbitone increases darolutamide clearance.
What to do
Avoid unless there is no alternative; prefer a non-inducing anticonvulsant. If used, monitor PSA and clinical response.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Darolutamide
Other interactions of Phenobarbitone
- Cabotegravir + Phenobarbitone Contraindicated
- Doravirine + Phenobarbitone Contraindicated
- Isavuconazole + Phenobarbitone Contraindicated
- Finerenone + Phenobarbitone Major
- Ivacaftor + Phenobarbitone Major
- Letermovir + Phenobarbitone Major
Frequently asked questions
Can I take Darolutamide with Phenobarbitone?
MediHelp rates the interaction as major. Darolutamide and Phenobarbitone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Phenobarbitone is expected to lower darolutamide exposure and may reduce anticancer efficacy.
How serious is the interaction between Darolutamide and Phenobarbitone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unless there is no alternative; prefer a non-inducing anticonvulsant. If used, monitor PSA and clinical response.
What other medicines interact with Darolutamide?
MediHelp also lists interactions of Darolutamide with, for example, Apalutamide, Carbamazepine, Efavirenz. The full list is on the Darolutamide page.
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