Drug interactions
Apalutamide + Darolutamide
Severity: Major
Apalutamide and Darolutamide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide may lower darolutamide concentrations, potentially reducing efficacy. Both are androgen receptor inhibitors and are not used together for the same indication.
What this interaction means in plain words
Apalutamide and Darolutamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Apalutamide belongs to Endocrine; Darolutamide belongs to Miscellaneous.
Why it happens
Induction of CYP3A4 and P-glycoprotein increases darolutamide clearance.
What to do
Avoid combining these agents; they are therapeutically duplicative, so choose a single antiandrogen.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Other interactions of Darolutamide
Frequently asked questions
Can I take Apalutamide with Darolutamide?
MediHelp rates the interaction as major. Apalutamide and Darolutamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Apalutamide may lower darolutamide concentrations, potentially reducing efficacy. Both are androgen receptor inhibitors and are not used together for the same indication.
How serious is the interaction between Apalutamide and Darolutamide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining these agents; they are therapeutically duplicative, so choose a single antiandrogen.
What other medicines interact with Apalutamide?
MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Cobicistat, Doravirine. The full list is on the Apalutamide page.
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