Drug interactions
Darolutamide + Glibenclamide
Severity: Moderate
Darolutamide and Glibenclamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darolutamide inhibits BCRP, a transporter that affects glyburide disposition. Higher glyburide exposure could increase hypoglycemia risk.
What this interaction means in plain words
Darolutamide and Glibenclamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darolutamide belongs to Miscellaneous; Glibenclamide belongs to Endocrine.
Why it happens
Inhibition of BCRP efflux transport increases glyburide absorption and exposure.
What to do
Monitor blood glucose when darolutamide is started. Consider reducing the glyburide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glibenclamide
- Bosentan + Glibenclamide Contraindicated
- Cholic acid + Glibenclamide Major
- Ciprofloxacin + Glibenclamide Major
- Clarithromycin + Glibenclamide Major
- Fluconazole + Glibenclamide Major
- Glibenclamide + Insulin degludec-liraglutide Major
Other interactions of Darolutamide
Frequently asked questions
Can I take Darolutamide with Glibenclamide?
MediHelp rates the interaction as moderate. Darolutamide and Glibenclamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Darolutamide inhibits BCRP, a transporter that affects glyburide disposition. Higher glyburide exposure could increase hypoglycemia risk.
How serious is the interaction between Darolutamide and Glibenclamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when darolutamide is started. Consider reducing the glyburide dose if hypoglycemia occurs.
What other medicines interact with Glibenclamide?
MediHelp also lists interactions of Glibenclamide with, for example, Bosentan, Cholic acid, Ciprofloxacin. The full list is on the Glibenclamide page.
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